Treatment routes
Every way ketamine is given, explained
Independent guides to IV, IM, and oral ketamine, SPRAVATO® esketamine nasal spray, and ketamine-assisted psychotherapy — with what's FDA-approved clearly separated from off-label use.
Not sure? Take the 5-question decision guide →Off-label
IV ketamine infusion
A slow drip into a vein in a monitored clinic room — the most-studied route for depression.
Read the guide Off-labelIM ketamine injection
An injection into a muscle, with a shorter session and no IV line.
Read the guide Off-labelOral & sublingual ketamine
Tablets or lozenges — the most accessible route, with the thinnest evidence.
Read the guide FDA-approved (specific uses)Esketamine nasal spray (SPRAVATO®)
The only FDA-approved ketamine-based medicine for depression — self-administered in a certified clinic.
Read the guide Therapy modelKetamine-assisted psychotherapy (KAP)
Ketamine sessions paired with structured therapy before, during, and after.
Read the guide