Ketamine Directory news desk
Original reporting based on FDA materials, official REMS information, peer-reviewed research, and other named primary sources.
Patient experience
The quality gap between ketamine clinics is enormous and the industry is lightly standardized. Ten questions that separate well-run programs from storefronts.
September 8, 2026 · Source: FDA Prescribing Information for SPRAVATO® (esketamine), revised January 2025
Read the updateLatest reporting
August 18, 2026
Clinics increasingly prescribe oral ketamine for supervised home protocols. The evidence is thinner than the marketing suggests — here's what's known, and the risks nobody mentions.
Primary source: FDA Prescribing Information for SPRAVATO® (esketamine), revised January 2025
July 28, 2026
Ketamine-based treatment is generally well tolerated in monitored settings, but the risks are real and labeled. What the boxed warnings mean, common side effects, and who should not get it.
Primary source: FDA Prescribing Information for SPRAVATO® (esketamine), revised January 2025
July 7, 2026
From the intake questions to the two-hour ride home: a realistic walk-through of a first IV ketamine session, including how the dissociative experience actually feels.
Primary source: FDA Prescribing Information for SPRAVATO® (esketamine), revised January 2025
June 16, 2026
SPRAVATO® is the one ketamine-based treatment insurers routinely cover — but only for two approved uses, and only after prior authorization. Here's the sequence.
Primary source: FDA Prescribing Information for SPRAVATO® (esketamine), revised January 2025
May 26, 2026
IV infusions, IM injections, oral ketamine, and SPRAVATO® all price very differently — and insurance only reliably covers one of them. A realistic cost breakdown.
Primary source: FDA Prescribing Information for SPRAVATO® (esketamine), revised January 2025
May 5, 2026
Ketamine and esketamine are related but not interchangeable — one is an FDA-approved, REMS-controlled nasal spray, the other a 60-year-old anesthetic used off-label. Here's how they differ.
Primary source: FDA Prescribing Information for SPRAVATO® (esketamine), revised January 2025
April 14, 2026
The complete guide to ketamine-based treatment: IV, IM, oral, and esketamine nasal spray, which conditions the evidence supports, what treatment costs, and how to pick a qualified clinic.
Primary source: FDA Prescribing Information for SPRAVATO® (esketamine), revised January 2025
News tells you what changed. These guides explain approved uses, monitored treatment, safety, insurance, and questions to ask a treatment center.
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