Therapy model

Ketamine-assisted psychotherapy (KAP)

Ketamine-assisted psychotherapy (KAP) combines a ketamine dose — commonly IM, sublingual, or IV — with talk therapy. It is a treatment model rather than a separate medicine, and the ketamine itself is used off-label.

FDA status
The ketamine used is off-label; KAP is a clinical practice model
Structure
Preparation, dosing session(s), and integration therapy
Team
Prescriber plus a licensed therapist
Coverage
Therapy portions are sometimes billable; ketamine usually self-pay

How KAP works

Preparation sessions set goals and safety plans. During dosing, a therapist may be present or you may rest quietly. Integration sessions afterward help you process the experience and apply insights to daily life.

What the evidence shows

Research on combining ketamine with psychotherapy is promising but early, with mostly small studies. Ask providers how they measure progress.

Safety

Ketamine can cause dissociation, sedation, raised blood pressure, nausea, and dizziness, and it can be misused. A licensed prescriber must evaluate your full medical and psychiatric history first, and you should never drive until the next day.

Common questions

Do I need a therapist already?

Not necessarily. Many KAP programs include their own therapist; others coordinate with your existing one.

This guide is educational and not medical advice. If you are in crisis, call or text 988.

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